Endocrine Abstracts

Introduction: Appropriately titrated levothyroxine (L-T4) replacement therapy may not be able to fully correct the entire set of metabolic defects afflicting individuals with primary hypothyroidism. Based on this hypothesis, the present study was undertaken to establish whether these patients have impaired whole body energy metabolism.Methods: We recruited 30 hypothyroid women with duration of the disease >2 years, BMI >...

Hypothyroidism is a risk factor for obesity, central adiposity and ectopic fat accumulation. To assess whether this risk could be detected also in stable patients taking regularly the LT4 replacement therapy we assessed retrospectively the prevalence of metabolic syndrome (ATP III definition) and calculated the fatty liver index (FLI) and the visceral adiposity index (VAI) in patients attending our Outpatient Endocrinology Clinic because of known primary acquired hy...

Increased serum TSH has been reported in obese children and adolescents and is considered an adaptive mechanism secondary to obesity. This study was undertaken to test the hypothesis that this adaptation is not associated with obesity per se but with its related metabolic alterations. Using a cross-sectional approach, we collected retrospectively fasting serum TSH concentration (if within the normal range), anthropometric parameters and criteria for the diagnosis of t...

Background: 20% of the familial isolated pituitary adenoma (FIPA) population harbour an aryl hydrocarbon receptor-interacting protein (AIP) gene mutation. The recognition of whether a variant is pathogenic can be difficult, in cases where the observed change does not lead to a truncated protein. Segregation with disease in a family, in silico predictions, loss of heterozigosity in the tumour, in vitro functional studies and screening of the variant in controls may help in asce...